Article
Treatment with human, recombinant FSH improves sperm DNA fragmentation in idiopathic infertile men depending on the FSH receptor polymorphism p.N680S: a pharmacogenetic study.
Human reproduction (Oxford, England) - 1 Sept 2016
Simoni Manuela, Santi Daniele, Negri Luciano, Hoffmann Ivan, Muratori Monica, Baldi Elisabetta, Cambi Marta, Marcou Marios, Greither Thomas, Baraldi Enrica, Tagliavini Simonetta, Carra Daniela, Lombardo Francesco, Gandini Loredana, Pallotti Francesco, Krausz Csilla, Rastrelli Giulia, Ferlin Alberto, Menegazzo Massimo, Pignatti Elisa, Linari Francesca, Marino Marco, Benaglia Renzo, Levi-Setti Paolo E, Behre Hermann M
Abstract excerpt
STUDY QUESTION: Does the sperm DNA fragmentation index (DFI) improve depending on the FSH receptor (FSHR) genotype as assessed by the nonsynonymous polymorphisms rs6166 (p.N680S) after 3 months of recombinant FSH treatment in men with idiopathic infertility? SUMMARY ANSWER: FSH treatment significantly improves sperm DFI only in idiopathic infertile men with the p.N680S homozygous N FSHR. WHAT IS KNOWN ALREADY:...
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