Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.

Neuroscience letters - 15 Aug 2016

Yamada Hiroshi, Kobayashi Kinue, Zhang Yubai, Takeda Tetsuya, Takei Kohji

Abstract excerpt

Specific mutations in dynamin 2 are linked to Charcot-Marie-Tooth disease (CMT), an inherited peripheral neuropathy. However, the effects of these mutations on dynamin function, particularly in relation to the regulation of the actin cytoskeleton remain unclear. Here, selected CMT-associated dynamin mutants were expressed to examine their role in the pathogenesis of CMT in U2OS cells. Ectopic expression of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Charcot-Marie-Tooth Disease

Share to Dynamin II

Share to Mutation

Share to Pseudopodia

Source

Identifiers

PMID: 27328317
DOI: 10.1016/j.neulet.2016.06.030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of a dynamin 2 mutant associated with Charcot-Marie-Tooth disease leads to aberrant actin dynamics and lamellipodia formation.PMID 27328317Read ↗

Dynamic instability of microtubules requires dynamin 2 and is impaired in a Charcot-Marie-Tooth mutant.Semantic proximity Read ↗

Insights into wild-type dynamin 2 and the consequences of DNM2 mutations from transgenic zebrafish.Semantic proximity Read ↗

Mild functional differences of dynamin 2 mutations associated to centronuclear myopathy and Charcot-Marie Tooth peripheral neuropathy.Semantic proximity Read ↗

Common membrane trafficking defects of disease-associated dynamin 2 mutations.Semantic proximity Read ↗

Mutations in the pleckstrin homology domain of dynamin 2 cause dominant intermediate Charcot-Marie-Tooth disease.Semantic proximity Read ↗

Dynamin 2 mutations in Charcot-Marie-Tooth neuropathy highlight the importance of clathrin-mediated endocytosis in myelination.Semantic proximity Read ↗

Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis.Semantic proximity Read ↗

Dynamin-2 mutations associated with centronuclear myopathy are hypermorphic and lead to T-tubule fragmentation.Semantic proximity Read ↗

A mutation associated with Charcot-Marie-Tooth disease enhances the formation of stable dynamin 2 complexes in cellsSemantic proximity Read ↗

Oligomerization of dynamin superfamily proteins in health and disease.Semantic proximity Read ↗

Dynamin-2 mutations linked to Centronuclear Myopathy impair actin-dependent trafficking in muscle cells.Semantic proximity Read ↗

Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.