Article
Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2016
Moon Robert W, Sharaf Hazem, Hastings Claire H, Ho Yung Shwen, Nair Mridul B, Rchiad Zineb, Knuepfer Ellen, Ramaprasad Abhinay, Mohring Franziska, Amir Amirah, Yusuf Noor A, Hall Joanna, Almond Neil, Lau Yee Ling, Pain Arnab, Blackman Michael J, Holder Anthony A
Abstract excerpt
The dominant cause of malaria in Malaysia is now Plasmodium knowlesi, a zoonotic parasite of cynomolgus macaque monkeys found throughout South East Asia. Comparative genomic analysis of parasites adapted to in vitro growth in either cynomolgus or human RBCs identified a genomic deletion that includes the gene encoding normocyte-binding protein Xa (NBPXa) in parasites growing in cynomolgus RBCs but not in human...
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