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Distinct genetic difference between the Duffy binding protein (PkDBPαII) of Plasmodium knowlesi clinical isolates from North Borneo and Peninsular Malaysia.

Malaria journal - 21 Feb 2015

Fong Mun-Yik, Rashdi Sarah A A, Yusof Ruhani, Lau Yee-Ling

Abstract excerpt

BACKGROUND: Plasmodium knowlesi is one of the monkey malaria parasites that can cause human malaria. The Duffy binding protein of P. knowlesi (PkDBPαII) is essential for the parasite's invasion into human and monkey erythrocytes. A previous study on P. knowlesi clinical isolates from Peninsular Malaysia reported high level of genetic diversity in the PkDBPαII. Furthermore, 36 amino acid haplotypes were identified...

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PMID: 25890095
DOI: 10.1186/s12936-015-0610-x
PMCID: PMC4339428

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