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Staphylococcus simulans recombinant lysostaphin: Production, purification, and determination of antistaphylococcal activity

1 May 2016

Abstract excerpt

Staphylococcus simulans lysostaphin is an endopeptidase lysing staphylococcus cell walls by cleaving pentaglycine cross-bridges in their peptidoglycan. A synthetic gene encoding S. simulans lysostaphin was cloned in Escherichia coli cells, and producer strains were designed. The level of produced biologically active lysostaphin comprised 6-30% of total E. coli cell protein (depending on E. coli M15 or BL21...

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PMID: 27297900
DOI: 10.1134/s0006297916050072

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