Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Counselling framework for moderate-penetrance cancer-susceptibility mutations.

Nature reviews. Clinical oncology - 1 Sept 2016

Tung Nadine, Domchek Susan M, Stadler Zsofia, Nathanson Katherine L, Couch Fergus, Garber Judy E, Offit Kenneth, Robson Mark E

Abstract excerpt

The use of multigene panels for the assessment of cancer susceptibility is expanding rapidly in clinical practice, particularly in the USA, despite concerns regarding the uncertain clinical validity for some gene variants and the uncertain clinical utility of most multigene panels. So-called 'moderate-penetrance' gene mutations associated with cancer susceptibility are identified in approximately 2-5% of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Early Detection of Cancer
Share to Genetic Counseling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Imaging

Share to Mammography

Share to Mastectomy

Share to Ovarian Neoplasms

Share to Pancreatic Neoplasms

Share to Penetrance

Source

Open in PubMed Open full text

Identifiers

PMID: 27296296
DOI: 10.1038/nrclinonc.2016.90
PMCID: PMC5513673

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Counselling framework for moderate-penetrance cancer-susceptibility mutations.PMID 27296296Read ↗

A counseling framework for moderate-penetrance colorectal cancer susceptibility genes.Semantic proximity Read ↗

Updates on breast cancer genetics: Clinical implications of detecting syndromes of inherited increased susceptibility to breast cancer.Semantic proximity Read ↗

Reproductive decision-making in cancer susceptibility syndromes.Semantic proximity Read ↗

An updated counseling framework for moderate-penetrance colorectal cancer susceptibility genes.Semantic proximity Read ↗

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)Semantic proximity Read ↗

Multi-gene panel testing for hereditary cancer susceptibility in a rural Familial Cancer Program.Semantic proximity Read ↗

Population‐based genetic testing for cancer susceptibility genes: quo vadis?Semantic proximity Read ↗

Demographics and Clinical Decision Making in Patients with Germline Moderate Penetrance Non-BRCA Mutations in Breast Cancer Related Genes.Semantic proximity Read ↗

Cascade genetic testing for hereditary cancer syndromes: a review of barriers and breakthroughs.Semantic proximity Read ↗

Clinical interpretation of pathogenic ATM and CHEK2 variants on multigene panel tests: navigating moderate risk.Semantic proximity Read ↗

Clinician-Reported Impact of Germline Multigene Panel Testing on Cancer Risk Management Recommendations.Semantic proximity Read ↗

Update Swiss guideline for counselling and testing for predisposition to breast, ovarian, pancreatic and prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.