Article
Intercalated chemotherapy and erlotinib for non-small cell lung cancer (NSCLC) with activating epidermal growth factor receptor (EGFR) mutations.
Cancer biology & therapy - 2 Aug 2016
Zwitter Matjaz, Rajer Mirjana, Stanic Karmen, Vrankar Martina, Doma Andrej, Cuderman Anka, Grmek Marko, Kern Izidor, Kovac Viljem
Abstract excerpt
Among attempts to delay development of resistance to tyrosine kinase inhibitors (TKIs) in patients with advanced non-small cell lung cancer (NSCLC) with activating mutations of epidermal growth factor receptor (EGFR), intercalated therapy has not been properly evaluated. In a phase II trial, 38 patients with EGFR mutated NSCLC in advanced stage were treated with 4 to 6 3-weekly cycles of intercalated schedule...
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