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Article

Run-on of germline apoptosis promotes gonad senescence in C. elegans.

Oncotarget - 28 Jun 2016

de la Guardia Yila, Gilliat Ann F, Hellberg Josephine, Rennert Peter, Cabreiro Filipe, Gems David

Abstract excerpt

Aging (senescence) includes causal mechanisms (etiologies) of late-life disease, which remain poorly understood. According to the recently proposed hyperfunction theory, based on the older theory of antagonistic pleiotropy, senescent pathologies can arise from futile, post-reproductive run-on of processes that in early life promote fitness. Here we apply this idea to investigate the etiology of senescent...

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Identifiers

PMID: 27256978
DOI: 10.18632/oncotarget.9681
PMCID: PMC5129915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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