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Article

The genetic landscape of dural marginal zone lymphomas.

Oncotarget - 12 Jul 2016

Ganapathi Karthik A, Jobanputra Vaidehi, Iwamoto Fabio, Jain Preti, Chen Jinli, Cascione Luciano, Nahum Odelia, Levy Brynn, Xie Yi, Khattar Pallavi, Hoehn Daniela, Bertoni Francesco, Murty Vundavalli V, Pittaluga Stefania, Jaffe Elaine S, Alobeid Bachir, Mansukhani Mahesh M, Bhagat Govind

Abstract excerpt

The dura is a rare site of involvement by marginal zone lymphoma (MZL) and the biology of dural MZL is not well understood. We performed genome-wide DNA copy number and targeted mutational analysis of 14 dural MZL to determine the genetic landscape of this entity. Monoallelic and biallelic inactivation of TNFAIP3 by mutation (n=5) or loss (n=1) was observed in 6/9 (67%) dural MZL exhibiting plasmacytic...

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Topics

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Share to Chromosome Aberrations
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genetic Variation

Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, B-Cell, Marginal Zone

Share to Meningeal Neoplasms

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Source

Open in PubMed Open full text

Identifiers

PMID: 27248180
DOI: 10.18632/oncotarget.9678
PMCID: PMC5190007

Genes

NOTCH2
TNFAIP3
IGH
KLHL6
MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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