Article
Interrogating Genes That Mediate Chlamydia trachomatis Survival in Cell Culture Using Conditional Mutants and Recombination.
Journal of bacteriology - 1 Aug 2016
Brothwell Julie A, Muramatsu Matthew K, Toh Evelyn, Rockey Daniel D, Putman Timothy E, Barta Michael L, Hefty P Scott, Suchland Robert J, Nelson David E
Abstract excerpt
UNLABELLED: Intracellular bacterial pathogens in the family Chlamydiaceae are causes of human blindness, sexually transmitted disease, and pneumonia. Genetic dissection of the mechanisms of chlamydial pathogenicity has been hindered by multiple limitations, including the inability to inactivate genes that would prevent the production of elementary bodies. Many genes are also Chlamydia-specific genes, and...
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