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A platform supporting generation and isolation of random transposon mutants in Chlamydia trachomatis

14 Feb 2025

Abstract excerpt

ABSTRACT Chlamydia species represent a paradigm for understanding successful obligate intracellular parasitism. Despite limited genetic malleability, development of genetic tools has facilitated the elucidation of molecular mechanisms governing infectivity. Random mutagenesis approaches provide one of the most powerful strategies available to accomplish untargeted elucidation of gene function. Unfortunately,...

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PMID: 39950807
DOI: 10.1128/jb.00500-24

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