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Article

Effects of Mutations on Structure-Function Relationships of Matrix Metalloproteinase-1.

International journal of molecular sciences - 14 Oct 2016

Singh Warispreet, Fields Gregg B, Christov Christo Z, Karabencheva-Christova Tatyana G

Abstract excerpt

Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and conformational effects of such mutations, a molecular dynamics (MD) study was performed of in silico mutated residues in...

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Share to Catalytic Domain
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27754420
DOI: 10.3390/ijms17101727
PMCID: PMC5085758

Genes

CAT
HPX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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