Article
Evolutionary determinants of polycystic ovary syndrome: part 2.
Fertility and sterility - 1 Jul 2016
Fessler Daniel M T, Natterson-Horowitz Barbara, Azziz Ricardo
Abstract excerpt
Polycystic ovary syndrome (PCOS) is a prehistoric complex genetic trait, perhaps dating back at least 50,000 years. The disorder also represents an evolutionary paradox, demonstrating clear reproductive disadvantages (i.e., lack of evolutionary fitness), albeit persisting tens of thousands of years. Here we examine possible explanations for this paradox. We evaluate a variety of possible benefits accruing to...
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