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An Evolutionary Model for the Ancient Origins of Polycystic Ovary Syndrome

22 Sept 2023

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a common endocrinopathy of reproductive-aged women, characterized by hyperandrogenism, oligo-anovulation and insulin resistance and closely linked with preferential abdominal fat accumulation. As an ancestral primate trait, PCOS was likely further selected in humans when scarcity of food in hunter-gatherers of the late Pleistocene additionally programmed for enhanced fat...

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PMID: 37834765
DOI: 10.3390/jcm12196120

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