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Article

Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2.

Human mutation - 1 Sept 2016

Hilbers Florentine S, Luijsterburg Martijn S, Wiegant Wouter W, Meijers Caro M, Völker-Albert Moritz, Boonen Rick A, van Asperen Christi J, Devilee Peter, van Attikum Haico

Abstract excerpt

XRCC2 genetic variants have been associated with breast cancer susceptibility. However, association studies have been complicated because XRCC2 variants are extremely rare and consist mainly of amino acid substitutions whose grouping is sensitive to misclassification by the predictive algorithms. We therefore functionally characterized variants in XRCC2 by testing their ability to restore XRCC2-DNA repair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27233470
DOI: 10.1002/humu.23019

Genes

XRCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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