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Article

Rare variants in XRCC2 as breast cancer susceptibility alleles.

Journal of medical genetics - 1 Oct 2012

Hilbers Florentine S, Wijnen Juul T, Hoogerbrugge Nicoline, Oosterwijk Jan C, Collee Margriet J, Peterlongo Paolo, Radice Paolo, Manoukian Siranoush, Feroce Irene, Capra Fabio, Couch Fergus J, Wang Xianshu, Guidugli Lucia, Offit Kenneth, Shah Sohela, Campbell Ian G, Thompson Ella R, James Paul A, Trainer Alison H, Gracia Javier, Benitez Javier, van Asperen Christi J, Devilee Peter

Abstract excerpt

BACKGROUND: Recently, rare germline variants in XRCC2 were detected in non-BRCA1/2 familial breast cancer cases, and a significant association with breast cancer was reported. However, the breast cancer risk associated with these variants needs further evaluation. METHODS: The coding regions and...

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Source

Identifiers

PMID: 23054243
DOI: 10.1136/jmedgenet-2012-101191

Genes

XRCC2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23054243-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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