Article
Testing for the mediating role of endophenotypes using molecular genetic data in a twin study of ADHD traits.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2016
Pinto Rebecca, Asherson Philip, Ilott Nicholas, Cheung Celeste H M, Kuntsi Jonna
Abstract excerpt
Family and twin studies have identified endophenotypes that capture familial and genetic risk in attention-deficit/hyperactivity disorder (ADHD), but it remains unclear if they lie on the causal pathway. Here, we illustrate a stepwise approach to identifying intermediate phenotypes. First, we use previous quantitative genetic findings to delineate the expected pattern of genetically correlated phenotypes. Second,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.