Article
Two autopsy cases with Pelizaeus-Merzbacher disease phenotype of adult onset, without mutation of proteolipid protein gene.
Acta neuropathologica - 1 Jan 2000
Sasaki A, Miyanaga K, Ototsuji M, Iwaki A, Iwaki T, Takahashi S, Nakazato Y
Abstract excerpt
We report the autopsy cases of two brothers which are pathologically compatible with Pelizaeus-Merzbacher disease (PMD). Both patients had a late onset (at the ages of 29 and 42 years) and chronic neurological symptoms including tremor, ataxia and dementia. The T2-weighted magnetic resonance imaging of the younger brother demonstrated increased signal areas with sparing of small areas in the cerebral white...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.