Article
A comparative reference study for the validation of HLA-matching algorithms in the search for allogeneic hematopoietic stem cell donors and cord blood units.
HLA - 1 Jun 2016
Bochtler W, Gragert L, Patel Z I, Robinson J, Steiner D, Hofmann J A, Pingel J, Baouz A, Melis A, Schneider J, Eberhard H-P, Oudshoorn M, Marsh S G E, Maiers M, Müller C R
Abstract excerpt
The accuracy of human leukocyte antigen (HLA)-matching algorithms is a prerequisite for the correct and efficient identification of optimal unrelated donors for patients requiring hematopoietic stem cell transplantation. The goal of this World Marrow Donor Association study was to validate established matching algorithms from different international donor registries by challenging them with simulated input data...
Topics
- Algorithms
- Alleles
- Cord Blood Stem Cell Transplantation
- Datasets as Topic
- Gene Frequency
- HLA Antigens
- Haplotypes
- Hematopoietic Stem Cell Transplantation
- Histocompatibility Testing