Article
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 May 2016
Mirgal Darshana, Ghosh Kanjaksha, Mahanta Jagadish, Dutta Prafulla, Shetty Shrimati
Abstract excerpt
BACKGROUND: Recent studies in experimental mice have shown that mild deficiency of methylenetetrahydrofolate reductase (MTHFR) enzyme confers protection against malaria, thus providing an important basis for the hypothesis that MTHFR polymorphism, i.e. C677T, might have been subjected to selection pressure against malaria. The present study was undertaken in a malaria endemic region in North East India to assess...
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