The Challenges of Implementing Next Generation Sequencing Across a Large Healthcare System, and the Molecular Epidemiology and Antibiotic Susceptibilities of Carbapenemase-Producing Bacteria in the Healthcare System of the U.S. Department of Defense.

doi:10.1371/journal.pone.0155770

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The Challenges of Implementing Next Generation Sequencing Across a Large Healthcare System, and the Molecular Epidemiology and Antibiotic Susceptibilities of Carbapenemase-Producing Bacteria in the Healthcare System of the U.S. Department of Defense.

PloS one - 1 Jan 2016

Lesho Emil, Clifford Robert, Onmus-Leone Fatma, Appalla Lakshmi, Snesrud Erik, Kwak Yoon, Ong Ana, Maybank Rosslyn, Waterman Paige, Rohrbeck Patricia, Julius Michael, Roth Amanda, Martinez Joshua, Nielsen Lindsey, Steele Eric, McGann Patrick, Hinkle Mary

Abstract excerpt

OBJECTIVE: We sought to: 1) provide an overview of the genomic epidemiology of an extensive collection of carbapenemase-producing bacteria (CPB) collected in the U.S. Department of Defense health system; 2) increase awareness of the public availability of the sequences, isolates, and customized antimicrobial resistance database of that system; and 3) illustrate challenges and offer mitigations for implementing...

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PMID: 27196272
DOI: 10.1371/journal.pone.0155770
PMCID: PMC4873006

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