Article
GR gene polymorphism is associated with inter-subject variability in response to glucocorticoids in patients with myasthenia gravis.
European journal of neurology - 1 Aug 2016
Xie Y, Meng Y, Li H-F, Hong Y, Sun L, Zhu X, Yue Y-X, Gao X, Wang S, Li Y, Kusner L L, Kaminski H J
Abstract excerpt
BACKGROUND AND PURPOSE: Glucocorticoids (GCs) are the mainstay treatment of myasthenia gravis (MG). However, wide inter-individual variability exists in the response to GCs. METHODS: A Chinese cohort of 257 MG patients treated with GCs was evaluated for the association between 19 single nucleotide polymorphisms in the GR gene and clinical response to the initial 3 month GC therapy. A quantitative MG score...
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