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Article

Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma: Characterization in a 3D-cell culture model.

World journal of gastroenterology - 14 May 2016

Gagliano Nicoletta, Celesti Giuseppe, Tacchini Lorenza, Pluchino Stefano, Sforza Chiarella, Rasile Marco, Valerio Vincenza, Laghi Luigi, Conte Vincenzo, Procacci Patrizia

Abstract excerpt

AIM: To analyze the effect of three-dimensional (3D)-arrangement on the expression of epithelial-to-mesenchymal transition markers in pancreatic adenocarcinoma (PDAC) cells. METHODS: HPAF-II, HPAC, and PL45 PDAC cells were cultured in either 2D-monolayers or 3D-spheroids. Ultrastructure was analyzed by transmission electron microscopy. The expression of E-cadherin, β-catenin, N-cadherin, collagen type I (COL-I),...

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Identifiers

PMID: 27182158
DOI: 10.3748/wjg.v22.i18.4466
PMCID: PMC4858630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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