Relationship between cancer mutations and parameter sensitivity in Rb pathway.

Abstract excerpt

It has long been known that formation of all sorts of tumors is largely owing to the genomic variations. Oncogenic mutations are often found focused on one or more important pathways which indicate that it is meaningful to investigate oncogenic mutations and oncogenic mechanisms from the point of view of biological network. Recently, we found that in apoptosis pathway of mammalian cell, mutations that cause large...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cyclin-Dependent Kinase 2
• Share to Cyclin E
• Share to E2F Transcription Factors