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Article

To Cull or Not To Cull? Considerations for Studies of Endocrine-Disrupting Chemicals

13 May 2016

Abstract excerpt

The power of animal models is derived from the ability to control experimental variables so that observed effects may be unequivocally attributed to the factor that was changed. One variable that is difficult to control in animal experiments is the number and composition of offspring in a litter. To account for this variability, artificial equalization of the number of offspring in a litter (culling) is often...

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PMID: 27175970
DOI: 10.1210/en.2016-1145

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