Article
Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline.
Antimicrobial agents and chemotherapy - 1 Jul 2016
Larsen Jesper, Clasen Julie, Hansen Julie E, Paulander Wilhelm, Petersen Andreas, Larsen Anders R, Frees Dorte
Abstract excerpt
The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline....
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