Article
In the Wrong Place with the Wrong SNP: The Association Between Stressful Neighborhoods and Cardiac Arrest Within Beta-2-adrenergic Receptor Variants.
Epidemiology (Cambridge, Mass.) - 1 Sept 2016
Mooney Stephen J, Grady Stephanie T, Sotoodehnia Nona, Lemaitre Rozenn N, Wallace Erin R, Mohanty April F, Yee Jean, Siscovick David S, Rea Thomas D, McKnight Barbara, Kwok Pui-Yan, Mak Angel C Y, Hesselson Stephanie, Lovasi Gina S
Abstract excerpt
BACKGROUND: Sudden cardiac arrest has been linked independently both to stressful neighborhood conditions and to polymorphisms in the ADRB2 gene. The ADRB2 gene mediates sympathetic activation in response to stress. Therefore, if neighborhood conditions cause cardiac arrest through the stress pathway, the ADRB2 variant may modify the association between neighborhood conditions, such as socioeconomic deprivation...
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