Article
The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2016
Freitag Christine M, Lempp Thomas, Nguyen T Trang, Jacob Christian P, Weissflog Lena, Romanos Marcel, Renner Tobias J, Walitza Susanne, Warnke Andreas, Rujescu Dan, Lesch Klaus-Peter, Reif Andreas
Abstract excerpt
Previous linkage and genome wide association (GWA) studies in ADHD indicated astrotactin 2 (ASTN2) as a candidate gene for attention-deficit/hyperactivity disorder (ADHD). ASTN2 plays a key role in glial-guided neuronal migration. To investigate whether common variants in ASTN2 contribute to ADHD disorder risk, we tested 63 SNPs spanning ASTN2 for association with ADHD and specific comorbid disorders in two...
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