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Article

MiR-128 and miR-125 regulate expression of coagulation Factor IX gene with nonsense mutation by repressing nonsense-mediated mRNA decay.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 May 2016

Wang Gang, Chai Baofeng, Yang Linhua

Abstract excerpt

Hemophilia could be caused by a nonsense mutation of the Factor IX gene, leading to a deficiency of Factor IX (F9). The nonsense mutation frequency of F9 is more than 10% according to the database. Nonsense-mediated mRNA decay (NMD) is a defined cellular response that can potentially prevent the production of such deleterious C-terminal truncated proteins from aberrant mRNA. Here, we constructed a mini-gene of...

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PMID: 27133073
DOI: 10.1016/j.biopha.2016.03.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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