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Article

Molecular docking and simulation study for synthesis of alternative dapsone derivative as a newer antileprosy drug in multidrug therapy.

Journal of cellular biochemistry - 1 Dec 2018

Swain Shasank S, Paidesetty Sudhir K, Dehury Budheswar, Sahoo Jyotirmaya, Vedithi Sundeep Chaitanya, Mahapatra Namita, Hussain Tahziba, Padhy Rabindra N

Abstract excerpt

Leprosy (causative, Mycobacterium leprae) continues to be the persisting public health problem with stable incidence rates, owing to the emergence of dapsone resistance that being the principal drug in the ongoing multidrug therapy. Hence, to overcome the drug resistance, structural modification through medicinal chemistry was used to design newer dapsone derivative(s) (DDs), against folic acid biosynthesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30125973
DOI: 10.1002/jcb.27304

Genes

DHPS

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