Article
Designing an efficient multi-epitope peptide vaccine against Vibrio cholerae via combined immunoinformatics and protein interaction based approaches.
Computational biology and chemistry - 1 Jun 2016
Nezafat Navid, Karimi Zeinab, Eslami Mahboobeh, Mohkam Milad, Zandian Sanam, Ghasemi Younes
Abstract excerpt
Cholera continues to be a major global health concern. Among different Vibrio cholerae strains, only O1 and O139 cause acute diarrheal diseases that are related to epidemic and pandemic outbreaks. The currently available cholera vaccines are mainly lived and attenuated vaccines consisting of V. cholerae virulence factors such as toxin-coregulated pili (TCP), outer membrane proteins (Omps), and nontoxic cholera...
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