Article
A combined tissue-engineered/in silico signature tool patient stratification in lung cancer.
Molecular oncology - 1 Aug 2018
Göttlich Claudia, Kunz Meik, Zapp Cornelia, Nietzer Sarah L, Walles Heike, Dandekar Thomas, Dandekar Gudrun
Abstract excerpt
Patient-tailored therapy based on tumor drivers is promising for lung cancer treatment. For this, we combined in vitro tissue models with in silico analyses. Using individual cell lines with specific mutations, we demonstrate a generic and rapid stratification pipeline for targeted tumor therapy. We improve in vitro models of tissue conditions by a biological matrix-based three-dimensional (3D) tissue culture...
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