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Article

Genetic Diversity in the Major Capsid L1 Protein of HPV-16 and HPV-18 in the Netherlands.

PloS one - 1 Jan 2016

King Audrey J, Sonsma Jan A, Vriend Henrike J, van der Sande Marianne A B, Feltkamp Mariet C, Boot Hein J, Koopmans Marion P G

Abstract excerpt

OBJECTIVES: Intratypic molecular variants of human papillomavirus (HPV) type-16 and -18 exist. In the Netherlands, a bivalent vaccine, composed of recombinant L1 proteins from HPV-16 and -18, is used to prevent cervical cancer since 2009. Long-term vaccination could lead to changes in HPV-16 and -18 virus population, thereby hampering vaccination strategies. We determined the genetic diversity of the L1 gene in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27070907
DOI: 10.1371/journal.pone.0152782
PMCID: PMC4829201

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