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Article

Hyperhomocysteinemia and MTHFR C677T polymorphism in patients with portal vein thrombosis complicating liver cirrhosis.

Thrombosis research - 1 May 2016

Ventura Paolo, Venturelli Giorgia, Marcacci Matteo, Fiorini Massimo, Marchini Stefano, Cuoghi Chiara, Pietrangelo Antonello

Abstract excerpt

BACKGROUND: Portal vein thrombosis (PVT) is serious complication of liver cirrhosis (LC), especially in the presence of hepatocellular carcinoma (HCC). The liver plays a key role in homocysteine (Hcy) metabolism: mild hyperhomocysteinemia (HHcy) has been described in LC. HHcy is a risk factor for deep vein thrombosis. Methylen-tetrahydrofolate-reductase (MTHFR) C677T polymorphism is the commonest determinant of...

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Source

Identifiers

PMID: 27065203
DOI: 10.1016/j.thromres.2016.03.024

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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