Article
Contributions of Charged Residues in Structurally Dynamic Capsid Surface Loops to Rous Sarcoma Virus Assembly.
Journal of virology - 15 Jun 2016
Heyrana Katrina J, Goh Boon Chong, Perilla Juan R, Nguyen Tam-Linh N, England Matthew R, Bewley Maria C, Schulten Klaus, Craven Rebecca C
Abstract excerpt
UNLABELLED: Extensive studies of orthoretroviral capsids have shown that many regions of the CA protein play unique roles at different points in the virus life cycle. The N-terminal domain (NTD) flexible-loop (FL) region is one such example: exposed on the outer capsid surface, it has been implicated in Gag-mediated particle assembly, capsid maturation, and early replication events. We have now defined the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
