Article
Daclatasvir vs telaprevir plus peginterferon alfa/ribavirin for hepatitis C virus genotype 1.
World journal of gastroenterology - 28 Mar 2016
Jacobson Ira, Zeuzem Stefan, Flisiak Robert, Knysz Brygida, Lueth Stefan, Zarebska-Michaluk Dorota, Janczewska Ewa, Ferenci Peter, Diago Moises, Zignego Anna Linda, Safadi Rifaat, Baruch Yaacov, Abdurakhmanov Dzhamal, Shafran Stephen, Thabut Dominique, Bruck Rafael, Gadano Adrian, Thompson Alexander James, Kopit Justin, McPhee Fiona, Michener Tracy, Hughes Eric A, Yin Philip D, Noviello Stephanie
Abstract excerpt
AIM: To evaluate daclatasvir vs telaprevir, each combined with peginterferon alfa-2a/ribavirin (pegIFN/RBV), in treatment-naive hepatitis C virus (HCV) genotype (GT) 1-infected patients. METHODS: In this phase 3, randomized, open-label, noninferiority study, 602 patients were randomly assigned (2:1) to daclatasvir vs telaprevir, stratified by IL28B rs12979860 host genotype (CC vs non-CC), cirrhosis status...
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