Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.

Molecular neurobiology - 1 May 2017

Wang Xin, Li Nuomin, Xiong Nian, You Qi, Li Jie, Yu Jinlong, Qing Hong, Wang Tao, Cordell Heather J, Isacson Ole, Vance Jeffery M, Martin Eden R, Zhao Ying, Cohen Bruce M, Buttner Edgar A, Lin Zhicheng

Abstract excerpt

The cytoskeleton not only provides structure, it is an active component of cell function, and in several neurodegenerative disorders, there is evidence of cytoskeletal collapse. Cytoskeletal proteins have been specifically implicated in the pathogenesis of Parkinson's disease (PD), where degeneration of dopaminergic (DA) neurons is the hallmark, but in which many factors may determine the resilience of DA neurons...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans Proteins
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Family

Share to Gene Knockdown Techniques

Share to Gene Knockout Techniques

Share to Microfilament Proteins

Share to Nerve Degeneration

Share to Protein Isoforms

Source

Identifiers

PMID: 27021023
DOI: 10.1007/s12035-016-9861-y

Genes

MACF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.PMID 27021023Read ↗

Multiple roles for the cytoskeleton in ALSSemantic proximity Read ↗

Insights from Single-Cell RNA-seq: Identifying the Actin Gene Family as Novel Drivers in Parkinson’s DiseaseSemantic proximity Read ↗

Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanismSemantic proximity Read ↗

Duplication in the Microtubule-Actin Cross-linking Factor 1 gene causes a novel neuromuscular conditionSemantic proximity Read ↗

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALSSemantic proximity Read ↗

DCTN1 mutations in Perry syndrome.Semantic proximity Read ↗

Isoforms, structures, and functions of versatile spectraplakin MACF1Semantic proximity Read ↗

Mutations in the microtubule-associated protein 1A (Map1a) gene cause Purkinje cell degeneration.Semantic proximity Read ↗

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Semantic proximity Read ↗

Impaired retrograde transport by the Dynein/Dynactin complex contributes to Tau-induced toxicitySemantic proximity Read ↗

The MAP1 family of microtubule-associated proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.