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Article

Role of Biomarkers in the Development of PARP Inhibitors

1 Jan 2016

Abstract excerpt

Defects in DNA repair lead to genomic instability and play a critical role in cancer development. Understanding the process by which DNA damage repair is altered or bypassed in cancer may identify novel therapeutic targets and lead to improved patient outcomes. Poly(adenosine diphosphate-ribose) polymerase 1 (PARP1) has an important role in DNA repair, and novel therapeutics targeting PARP1 have been developed to...

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PMID: 26997874
DOI: 10.4137/bic.s36679

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