Article
The p.Gly61Glu Mutation in CYP1B1 Affects the Extracellular Matrix in Glaucoma Patients.
Ophthalmic research - 1 Jul 2016
Safari Iman, Suri Fatemeh, Haji-Seyed-Javadi Ramona, Yazdani Shahin, Elahi Elahe
Abstract excerpt
PURPOSE: The aim of this work was to assess the possible effects of CYP1B1 mutations on the extracellular matrix (ECM) in glaucoma patients. CYP1B1 mutations are the cause of disease in a notable fraction of primary congenital glaucoma (PCG) patients and in a smaller fraction of primary open angle glaucoma (POAG) patients. METHODS: The study was performed on a glaucoma family with the common homozygous p.Gly61Glu...
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