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Article

Spironolactone blocks Epstein–Barr virus production by inhibiting EBV SM protein function

14 Mar 2016

Abstract excerpt

Clinically available drugs active against Epstein-Barr virus (EBV) and other human herpesviruses are limited to those targeting viral DNA replication. To identify compounds directed against other steps in the viral life cycle, we searched for drugs active against the EBV SM protein, which is essential for infectious virus production. SM has a highly gene-specific mode of action and preferentially enhances...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 26976570
DOI: 10.1073/pnas.1523686113

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