Article
A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.
PloS one - 1 Jan 2016
Cigliola Valentina, Populaire Celine, Pierri Ciro L, Deutsch Samuel, Haefliger Jacques-Antoine, Fadista João, Lyssenko Valeriya, Groop Leif, Rueedi Rico, Thorel Fabrizio, Herrera Pedro Luis, Meda Paolo
Abstract excerpt
Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed in type 2 diabetes (T2D). GJD2 is also expressed in neurons, which share a number of common features with pancreatic β-cells. Given...
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