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TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells

3 Mar 2016

Abstract excerpt

Human urine cells (HUCs) can be reprogrammed into neural progenitor cells (NPCs) or induced pluripotent stem cells (iPSCs) with defined factors and a small molecule cocktail, but the underlying fate choice remains unresolved. Here, through sequential removal of individual compound from small molecule cocktail, we showed that A8301, a TGFβ signaling inhibitor, is sufficient to switch the cell fate from iPSCs into...

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PMID: 26935433
DOI: 10.1038/srep22484

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