Article
A Helitron transposon reconstructed from bats reveals a novel mechanism of genome shuffling in eukaryotes.
Nature communications - 2 Mar 2016
Grabundzija Ivana, Messing Simon A, Thomas Jainy, Cosby Rachel L, Bilic Ilija, Miskey Csaba, Gogol-Döring Andreas, Kapitonov Vladimir, Diem Tanja, Dalda Anna, Jurka Jerzy, Pritham Ellen J, Dyda Fred, Izsvák Zsuzsanna, Ivics Zoltán
Abstract excerpt
Helitron transposons capture and mobilize gene fragments in eukaryotes, but experimental evidence for their transposition is lacking in the absence of an isolated active element. Here we reconstruct Helraiser, an ancient element from the bat genome, and use this transposon as an experimental tool to unravel the mechanism of Helitron transposition. A hairpin close to the 3'-end of the transposon functions as a...
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