Article
The Implicitome: A Resource for Rationalizing Gene-Disease Associations.
PloS one - 1 Jan 2016
Hettne Kristina M, Thompson Mark, van Haagen Herman H H B M, van der Horst Eelke, Kaliyaperumal Rajaram, Mina Eleni, Tatum Zuotian, Laros Jeroen F J, van Mulligen Erik M, Schuemie Martijn, Aten Emmelien, Li Tong Shu, Bruskiewich Richard, Good Benjamin M, Su Andrew I, Kors Jan A, den Dunnen Johan, van Ommen Gert-Jan B, Roos Marco, 't Hoen Peter A C, Mons Barend, Schultes Erik A
Abstract excerpt
High-throughput experimental methods such as medical sequencing and genome-wide association studies (GWAS) identify increasingly large numbers of potential relations between genetic variants and diseases. Both biological complexity (millions of potential gene-disease associations) and the accelerating rate of data production necessitate computational approaches to prioritize and rationalize potential gene-disease...
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