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Article

Identifying genes targeted by disease-associated non-coding SNPs with a protein knowledge graph.

PloS one - 1 Jan 2022

Vlietstra Wytze J, Vos Rein, van Mulligen Erik M, Jenster Guido W, Kors Jan A

Abstract excerpt

Genome-wide association studies (GWAS) have identified many single nucleotide polymorphisms (SNPs) that play important roles in the genetic heritability of traits and diseases. With most of these SNPs located on the non-coding part of the genome, it is currently assumed that these SNPs influence the expression of nearby genes on the genome. However, identifying which genes are targeted by these disease-associated...

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PMID: 35830458
DOI: 10.1371/journal.pone.0271395
PMCID: PMC9278741

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