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Article

How Does Tobacco Smoke Contribute to Cervical Carcinogenesis?

22 May 2008

Abstract excerpt

Tobacco smoke is a well-established human papillomavirus (HPV) cofactor for the development of cervical precancer and cancer (3, 6), but the molecular mechanisms by which smoking increases the risk of cervical precancer and cancer remain unknown. There are several plausible explanations (2). One is that smoking inhibits the immune response to HPV. A second is that carcinogenic HPV-infected cells are exposed to...

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PMID: 18497423
DOI: 10.1128/jvi.00103-08

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