Article
Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt).
Congenital anomalies - 1 Jul 2016
Sawada Kazuhiko, Saito Shigeyoshi, Sugasawa Akari, Sato Chika, Aoyama Junya, Ohara Naoko, Horiuchi-Hirose Miwa, Kobayashi Tetsuya
Abstract excerpt
Growth-retarded mouse (grt/grt) is a spontaneous mutant that is known as an animal model for primary congenital hypothyroidism caused by resistance to TSH signaling. The regional pattern of cerebral cortical hypoplasia was characterized in grt/grt mice. Ex vivo computed tomography (CT)-based volumetry was examined in four regions of the cerebral cortex, i.e., prefrontal, frontal, parietal and occipito-temporal...
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