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Article

An Energy-Independent Pro-longevity Function of Triacylglycerol in Yeast.

PLoS genetics - 1 Feb 2016

Handee Witawas, Li Xiaobo, Hall Kevin W, Deng Xiexiong, Li Pan, Benning Christoph, Williams Barry L, Kuo Min-Hao

Abstract excerpt

Intracellular triacylglycerol (TAG) is a ubiquitous energy storage lipid also involved in lipid homeostasis and signaling. Comparatively, little is known about TAG's role in other cellular functions. Here we show a pro-longevity function of TAG in the budding yeast Saccharomyces cerevisiae. In yeast strains derived from natural and laboratory environments a correlation between high levels of TAG and longer...

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Identifiers

PMID: 26907989
DOI: 10.1371/journal.pgen.1005878
PMCID: PMC4764362

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