Article
Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases
23 Feb 2016
Abstract excerpt
Systemic autoimmune diseases are characterized by specific targeting of a limited group of ubiquitously expressed autoantigens by the immune system. This review examines the mechanisms underlying their selection as immune targets. Initiation of autoimmune responses likely reflects the presentation of antigens with a distinct structure not previously encountered by the immune system, in a proimmune context...
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