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Article

A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations.

Scientific reports - 23 Feb 2016

Bojsen Rasmus, Regenberg Birgitte, Gresham David, Folkesson Anders

Abstract excerpt

Fungal infections are an increasing clinical problem. Decreased treatment effectiveness is associated with biofilm formation and drug recalcitrance is thought to be biofilm specific. However, no systematic investigations have tested whether resistance mechanisms are shared between biofilm and planktonic populations. We performed multiplexed barcode sequencing (Bar-seq) screening of a pooled collection of...

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PMID: 26903175
DOI: 10.1038/srep21874
PMCID: PMC4763212

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